Say hello to my little friend - woolly mammoth

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From the UK Telegraph:

Japanese scientists take 'significant step' towards bringing the woolly mammoth back to life
With their enormous shaggy torsos and long curved tusks, the imposing creatures last walked on earth during the Ice Age.

Fast forward thousands of years and the woolly mammoth may once again make an appearance on this planet – after Japanese scientists claim to have taken a “significant step” towards bringing the long-extinct animals back to life.

Researchers extracted bone marrow and muscle tissue from the remains of a mammoth named Yuka, who has lain frozen in Siberian permafrost for more than 28,000 years.

As a first step, the team, from Kindai University in Osaka, confirmed the authenticity of Yuka’s extracted tissue samples using whole-genome sequencing techniques.

Scientists then injected cell nuclei from the extinct woolly mammoth’s muscle tissue into mouse cell eggs - resulting in signs of biological activities, according to the study, published by Nature’s on-line journal Scientific Reports.

The paper is here: Nature: Scientific Reports

Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging
The 28,000-year-old remains of a woolly mammoth, named ‘Yuka’, were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components in the remains. Nucleus-like structures found in the tissue homogenate were histone- and lamin-positive by immunostaining. In the reconstructed oocytes, the mammoth nuclei showed the spindle assembly, histone incorporation and partial nuclear formation; however, the full activation of nuclei for cleavage was not confirmed. DNA damage levels, which varied among the nuclei, were comparable to those of frozen-thawed mouse sperm and were reduced in some reconstructed oocytes. Our work provides a platform to evaluate the biological activities of nuclei in extinct animal species.

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This page contains a single entry by DaveH published on March 16, 2019 1:17 PM.

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