Just wonderful - Botox may be bad for you - really really bad

Interesting article at Newsweek regarding some potential serious problems with heavy Botox users.

A New Reason to Frown
Does Botox get into the brain? Troubling research contradicts earlier findings about the treatment

The way it usually works is, the rats and mice die first. Or at least get sick first. Or at the very least, show some adverse effect first - as in, before people do. The reason countless lab animals have given their lives during the testing of experimental drugs is to allow manufacturers and regulators to see that a compound might be toxic, even deadly, before millions of people use it. And if the compound does look a little dodgy, the lab-animal tests uncover the reason - how the compound affects the liver, say, or reaches the brain. Not surprisingly, these "preclinical tests" (that is, those performed before testing on humans) were especially rigorous for botulinum. One of the deadliest poisons in nature and a possible bioterrorism agent, this neurotoxin reached the market, in very dilute doses, starting in 1989 as Botox. A big reason Botox and its cousins, such as Myobloc, were OK'd was that preclinical testing showed that after being injected, they did not travel along the body's highways 'nerve cells' to the brain and spinal cord. Yes, there was some evidence the toxin slipped into the bloodstream or the lymph system, but Botox in the bloodstream cannot enter the brain, says its manufacturer.

Oops. In a reversal of the usual sequence in science, researchers have discovered, after millions of people have received the drug, something fundamental about how Botox can act. Contrary to what turned up in preclinical testing, botulinum toxin can travel along neurons from the injection site into the brain, at least in lab animals. Researchers at Italy's Institute of Neuroscience injected rats and mice with botulinum neurotoxin A in doses comparable to those used in people. (Strains are named A, B and E, depending on where the common soil bacteria that produce them live; A is Botox, B is Myobloc, which is used for severe back pain.) Neurons at the injection site the whisker muscles absorbed some of the toxin and passed it along to other neurons they connected to, the researchers report this month in The Journal of Neuroscience. Within three days, the toxin had migrated from the whisker muscles to the brainstem, where it disrupted neuronal activity. "The discovery was quite serendipitous ... and surprising," Matteo Caleo, who led the study, told the journal Science. "A significant portion of the toxin is active where it's not intended to be."

"migrated from the whisker muscles to the brainstem, where it disrupted neuronal activity" Just wonderful -- maybe this explains why there are so many "troofers" and political loonies out in Hollywood...

May 2016

Sun Mon Tue Wed Thu Fri Sat
1 2 3 4 5 6 7
8 9 10 11 12 13 14
15 16 17 18 19 20 21
22 23 24 25 26 27 28
29 30 31        

Environment and Climate
Cliff Mass Weather Blog
Climate Audit
Climate Depot
Green Trust
Jennifer Marohasy
Planet Gore
Science and Public Policy Institute
Solar Cycle 24
Space Weather
Space Weather - Canada
the Air Vent
Tom Nelson
Watts Up With That?

Science and Medicine
Derek Lowe
Junk Science
Life in the Fast Lane
Luboš Motl
New Scientist
Next Big Future
Ptak Science Books
Science Blog

Geek Stuff
Ars Technica
Boing Boing
Don Lancaster's Guru's Lair
Evil Mad Scientist Laboratories
Hack a Day
Kevin Kelly - Cool Tools
Slashdot: News for nerds
The Register
The Daily WTF

The Argyle Sweater
Chip Bok
Broadside Cartoons
Day by Day
Medium Large
Michael Ramirez
Prickly City
User Friendly
What The Duck

Awkward Family Photos
Cake Wrecks
Not Always Right
Sober in a Nightclub
You Drive What?

Business and Economics
The Austrian Economists
Carpe Diem
Coyote Blog

Photography and Art
Digital Photography Review
James Gurney
Joe McNally's Blog
The Online Photographer

A Western Heart
American Digest
The AnarchAngel
Anti-Idiotarian Rottweiler
Babalu Blog
Belmont Club
Bayou Renaissance Man
Classical Values
Cold Fury
David Limbaugh
Defense Technology
Doug Ross @ Journal
Grouchy Old Cripple
Irons in the Fire
James Lileks
Lowering the Bar
Maggie's Farm
Marginal Revolution
Michael J. Totten
Mostly Cajun
Power Line
Questions and Observations
Rachel Lucas
Roger L. Simon
Sense of Events
Sound Politics
The Strata-Sphere
The Smallest Minority
The Volokh Conspiracy
Tim Blair
Weasel Zippers

Gone but not Forgotten...
A Coyote at the Dog Show
Bad Eagle
Steven DenBeste
democrats give conservatives indigestion
Cox and Forkum
The Diplomad
Priorities & Frivolities
Gut Rumbles
Mean Mr. Mustard 2.0
Neptunus Lex
Other Side of Kim
Ramblings' Journal
Sgt. Stryker
shining full plate and a good broadsword
A Physicist's Perspective
The Daily Demarche
Wayne's Online Newsletter

About this Entry

This page contains a single entry by DaveH published on April 15, 2008 8:44 PM.

Something I saw once - a great story from Mostly Cajun was the previous entry in this blog.

Wonderful news from Italy is the next entry in this blog.

Find recent content on the main index or look in the archives to find all content.

Monthly Archives


OpenID accepted here Learn more about OpenID
Powered by Movable Type 5.2.9