Never a big fan but I still drink Diet Pepsi (used to be Coke before they went WOKE).
This will raise a few eyebrows - from SciTechDaily:
Researchers Uncover How Sugar Substitutes (Artificial Sweeteners) Disrupt Liver Detoxification
Results from a new study suggest that two sugar substitutes disrupt the function of a protein that plays a vital role in liver detoxification and the metabolism of certain drugs. These sugar substitutes, also known as non-nutritive sweeteners, provide a sweet taste with few or no calories.
“With an estimated 40% of Americans regularly consuming non-nutritive sweeteners, it’s important to understand how they affect the body,” said Laura Danner, a doctoral student at the Medical College of Wisconsin. “In fact, many people don’t realize that these sweeteners are found in light or zero-sugar versions of yogurts and snack foods and even in non-food products like liquid medicines and certain cosmetics.”
The mechanism?
They found that acesulfame potassium and sucralose inhibited the activity of P-glycoprotein (PGP), which is also known as multidrug resistance protein 1 (MDR1). PGP is part of a family of transporters that work together to cleanse the body of toxins, drugs, and drug metabolites.
“We observed that sweeteners impacted PGP activity in liver cells at concentrations expected through consumption of common foods and beverages, far below the recommended FDA maximum limits,” said Stephanie Olivier Van Stichelen, PhD, who leads the research team. “To our knowledge, we are the first group to decipher the molecular mechanism by which non-nutritive sweeteners impact detoxification in the liver.”
The experiments also showed that the sweeteners stimulate transport activity and likely bind to PGP, and thus compete with and inhibit the transport of other substrates such as xenobiotics, drugs and their metabolites, short-chain lipids, and bile acids.
These are just the preliminary findings but still, if they bear out in clinical studies, it will shake up the "diet" sweetner industry quite a bit. Some big money there and they do not want anyone fscking with their rice bowl.
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